SMITH & NEPHEW EXU-DRY® WOUND DRESSINGS & GARMENTS
From: $177.00
Uniquely designed to minimize trauma, save nursing time and lower total dressing costs. Replaces non-adherent dressings, gauze and abdominal pads. Designed to minimize adherence and is more comfortable for patients during the between dressing changes. Its Anti-Shear Layer™ helps reduce friction and shearing. The one-piece, multi-layer sealed construction eliminates frayed edges, loose threads and linting. Will not disturb new granulation tissue. Non-occlusive, soft and pliable. Can be used as a wet or dry dressing on clean or contaminated wounds. Can be used with a variety of topical agents.
All Variations
| SKU | Stock | Size | Material | Packaging | Price | Quantity | Price Per | Add to Cart |
|---|---|---|---|---|---|---|---|---|
| SKU: SM-5999M38 | Stock: In Stock | Size: 24x36 | Material: Permeable Medium Absorbency | Packaging: 24 wound dressing pads per case | Price: $275.60 | Price Per: case | ||
| SKU: SM-5999MPG | Stock: In Stock | Size: Medium | Material: | Packaging: 20 hand dressings per case | Price: $334.03 | variation_pricing_suffix: case | ||
| SKU: SM-5999101 | Stock: In Stock | Size: 4x6 | Material: | Packaging: 25 slit tube dressings per box, 4 boxes per case (100 slit tube dressings total) | Price: $2,063.77 | variation_pricing_suffix: case | ||
| SKU: SM-5999L75 | Stock: In Stock | Size: 20x28 | Material: Crib Permeable | Packaging: 20 sheets per case | Price: $386.29 | variation_pricing_suffix: case | ||
| SKU: SM-5999BP1 | Stock: In Stock | Size: Adult | Material: | Packaging: 10 buttocks dressings per case | Price: $763.91 | variation_pricing_suffix: case | ||
| SKU: SM-5999FDL | Stock: In Stock | Size: Large | Material: | Packaging: 20 boot/foot dressings per case | Price: $591.88 | variation_pricing_suffix: case | ||
| SKU: SM-5999003 | Stock: In Stock | Size: 3 | Material: | Packaging: 50 wound dressing discs per box, 2 boxes per case (100 wound dressing discs total) | Price: $204.96 | variation_pricing_suffix: case | ||
| SKU: SM-5999LPL | Stock: In Stock | Size: Leg | Material: | Packaging: 20 leg dressings per case | Price: $722.37 | variation_pricing_suffix: case | ||
| SKU: SM-5999M24 | Stock: In Stock | Size: 15x24 | Material: | Packaging: 30 wound dressings per case | Price: $414.61 | variation_pricing_suffix: case | ||
| SKU: SM-5999LPA | Stock: In Stock | Size: Arm | Material: | Packaging: 20 arm dressings per case | Price: $564.79 | variation_pricing_suffix: case | ||
| SKU: SM-5999M37 | Stock: In Stock | Size: 24x36 | Material: Non-Permeable Medium Absorbency | Packaging: 24 pads per case | Price: $266.28 | variation_pricing_suffix: case | ||
| SKU: SM-5999006 | Stock: In Stock | Size: 6x9 | Material: | Packaging: 12 leg/arm dressings per box, 4 boxes per case (48 leg/arm dressings total) | Price: $240.00 | variation_pricing_suffix: case | ||
| SKU: SM-5999L73 | Stock: In Stock | Size: 36x72 | Material: Non-Permeable | Packaging: 15 sheets per case | Price: $403.24 | variation_pricing_suffix: case | ||
| SKU: SM-5999034 | Stock: In Stock | Size: 3x4 | Material: Full Absorbency | Packaging: 50 wound dressings per box, 2 boxes per case (100 wound dressings total) | Price: $566.50 | variation_pricing_suffix: case | ||
| SKU: SM-5999L74 | Stock: In Stock | Size: 36x72 | Material: Permeable | Packaging: 15 sheets per case | Price: $415.76 | variation_pricing_suffix: case | ||
| SKU: SM-5999MJ1 | Stock: In Stock | Size: Medium | Material: | Packaging: 10 burn jackets per case | Price: $778.54 | variation_pricing_suffix: case | ||
| SKU: SM-5999LPG | Stock: In Stock | Size: Large | Material: | Packaging: 20 hand dressings per case | Price: $389.30 | variation_pricing_suffix: case | ||
| SKU: SM-5999003S | Stock: In Stock | Size: 3 | Material: Medium Absorbency | Packaging: 50 slit discs per box, 2 boxes per case (100 slit discs total) | Price: $529.56 | variation_pricing_suffix: case | ||
| SKU: SM-5999028 | Stock: In Stock | Size: 20x28 | Material: | Packaging: 20 wound dressings per case | Price: $577.26 | variation_pricing_suffix: case | ||
| SKU: SM-5999NKB6 | Stock: In Stock | Size: Adult | Material: | Packaging: 10 neck dressings per case | Price: $389.16 | variation_pricing_suffix: case | ||
| SKU: SM-5999LJ1 | Stock: In Stock | Size: Large | Material: | Packaging: 10 burn jackets per case | Price: $839.58 | variation_pricing_suffix: case | ||
| SKU: SM-5999004120 | Stock: In Stock | Size: 4x6 | Material: Full Absorbency | Packaging: 10 wound dressings per box, 12 boxes per case (120 wound dressings total) | Price: $379.09 | variation_pricing_suffix: case | ||
| SKU: SM-5999024 | Stock: In Stock | Size: 15x24 | Material: | Packaging: 30 wound dressings per case | Price: $485.98 | variation_pricing_suffix: case | ||
| SKU: SM-5999M18 | Stock: In Stock | Size: 15x18 | Material: | Packaging: 30 wound dressings per case | Price: $349.58 | variation_pricing_suffix: case | ||
| SKU: SM-5999PTM | Stock: In Stock | Size: 2x3 | Material: | Packaging: 50 slit tube dressings per case | Price: $177.00 | variation_pricing_suffix: case | ||
| SKU: SM-5999L72 | Stock: In Stock | Size: 36x72 | Material: Non-Permeable | Packaging: 15 sheets per case | Price: $367.26 | variation_pricing_suffix: case | ||
| SKU: SM-5999FM1 | Stock: In Stock | Size: Adult | Material: | Packaging: 20 adult face dressings per case | Price: $263.91 | variation_pricing_suffix: case | ||
| SKU: SM-5999INC9 | Stock: In Stock | Size: 3x9 | Material: | Packaging: 50 incision dressings per case | Price: $300.17 | variation_pricing_suffix: case | ||
| SKU: SM-5999SJ1 | Stock: In Stock | Size: Small | Material: | Packaging: 10 burn jackets per case | Price: $527.58 | variation_pricing_suffix: case | ||
| SKU: SM-5999009 | Stock: In Stock | Size: 9x15 | Material: | Packaging: 30 leg/arm dressings per case | Price: $238.60 | variation_pricing_suffix: case | ||
| SKU: SM-5999034S | Stock: In Stock | Size: 3x4 | Material: Full Absorbency | Packaging: 50 slit tube dressings per case | Price: $180.85 | variation_pricing_suffix: case | ||
| SKU: SM-5999SV1 | Stock: In Stock | Size: Small (Child) | Material: | Packaging: 20 vests per case | Price: $536.70 | variation_pricing_suffix: case | ||
| SKU: SM-5999FDM | Stock: In Stock | Size: Medium (Child) | Material: | Packaging: 20 boot/foot dressings per case | Price: $487.05 | variation_pricing_suffix: case | ||
| SKU: SM-5999M36 | Stock: In Stock | Size: 24x36 | Material: Non-Permeable Heavy Absorbency | Packaging: 15 pads per case | Price: $195.23 | variation_pricing_suffix: case | ||
| SKU: SM-5999018 | Stock: In Stock | Size: 15x18 | Material: | Packaging: 30 wound dressings per case | Price: $405.92 | variation_pricing_suffix: case | ||
| SKU: SM-5999LV1 | Stock: In Stock | Size: Large | Material: | Packaging: 20 burn vests per case | Price: $722.37 | variation_pricing_suffix: case |
Uniquely designed to minimize trauma, save nursing time and lower total dressing costs. Replaces non-adherent dressings, gauze and abdominal pads. Designed to minimize adherence and is more comfortable for patients during the between dressing changes. Its Anti-Shear Layer™ helps reduce friction and shearing. The one-piece, multi-layer sealed construction eliminates frayed edges, loose threads and linting. Will not disturb new granulation tissue. Non-occlusive, soft and pliable. Can be used as a wet or dry dressing on clean or contaminated wounds. Can be used with a variety of topical agents.
| Weight | 9.4000 lbs |
|---|---|
| Dimensions | 10 × 10 × 10 in |
| Size | Arm, Large, Medium, Adult, Leg, Medium (Child), 24×36, 36×72, 20×28, 6×9, 9×15, 3, 3×4, 4×6, Small (Child), 15×18, 15×24, 2×3, Small, 3×9 |
| Material | Non-Permeable Heavy Absorbency, Non-Permeable Medium Absorbency, Non-Permeable, Permeable, Crib Permeable, Medium Absorbency, Full Absorbency, Permeable Medium Absorbency |
| Packaging | 20 arm dressings per case, 20 hand dressings per case, 20 adult face dressings per case, 10 neck dressings per case, 20 leg dressings per case, 20 boot/foot dressings per case, 15 pads per case, 24 pads per case, 15 sheets per case, 20 sheets per case, 12 leg/arm dressings per box, 4 boxes per case (48 leg/arm dressings total), 30 leg/arm dressings per case, 50 slit discs per box, 2 boxes per case (100 slit discs total), 50 slit tube dressings per case, 50 wound dressings per box, 2 boxes per case (100 wound dressings total), 10 wound dressings per box, 12 boxes per case (120 wound dressings total), 20 vests per case, 50 wound dressing discs per box, 2 boxes per case (100 wound dressing discs total), 30 wound dressings per case, 25 slit tube dressings per box, 4 boxes per case (100 slit tube dressings total), 10 buttocks dressings per case, 10 burn jackets per case, 20 burn vests per case, 50 incision dressings per case, 24 wound dressing pads per case, 20 wound dressings per case |
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Semaglutide API Product Description:
COA Available Product with NDC Code
Available in the US and Canada.
Semaglutide API is indicated for improving glycemic control in adults with type 2 diabetes mellitus, in conjunction with diet and exercise. The approved therapeutic doses are 0.5 mg and 1 mg. Type 2 diabetes is a chronic metabolic disorder characterized by high blood sugar, insulin resistance, and insufficient insulin production. The onset of this condition is linked to the inability of beta cells to respond to increased plasma glucose, predominantly caused by lifestyle factors such as overweight and obesity. The key feature of type 2 diabetes is insulin resistance, which reduces insulin’s effectiveness at normal concentrations. Insulin secretion is stimulated by incretins like glucagon-like peptide 1 (GLP-1), which also delays gastric emptying and induces satiety.
Mode of Action:
Semaglutide API enhances glucose control through various mechanisms, including increased insulin secretion, slower gastric emptying, and reduced postprandial glucagon and food intake. The drug mimics the activity of GLP-1, a key hormone in glucose management, thanks to structural modifications that improve its stability against degradation by enzymes like dipeptidyl peptidase-4 (DPP-4). These modifications also promote specific binding to plasma albumin and prevent incorrect binding of fatty acids, resulting in an extended half-life and improved patient compliance.
Pharmacodynamics:
Clinical trials show that semaglutide significantly reduces glycated hemoglobin (HbA1c) compared to other medications, including sitagliptin, exenatide, and insulin glargine U100. HbA1c is a standard measure of high glucose levels, reflecting long-term blood sugar control. Additionally, semaglutide has been shown to reduce body weight, lower fasting and postprandial glucose levels, and decrease fasting triglycerides and VLDL cholesterol.
Metabolism:
Semaglutide is slowly but extensively metabolized before excretion, with 83% of the administered dose found unchanged in plasma. Six different metabolites have been identified, with the major metabolite accounting for 7.7% of the dose. The drug is primarily degraded by enzymes such as DPP-4 and neural endopeptidase (NEP), which inactivate semaglutide and hydrolyze its peptide bonds.
Toxicity:
In preclinical studies, mild c-cell hyperplasia and other effects, including liver necrosis and centrilobular hypertrophy, were observed at doses significantly higher than those used clinically. High doses also resulted in ECG abnormalities and tissue vacuolation.
IUPAC:
17-{[(1R)-3-[(2-{2-[({2-[2-({[(5S)-5-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S,3R)-2-{2-[(2S)-2-{2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-2-methylpropanamido}-4-carboxybutanamido]acetamido}-3-hydroxybutanamido]-3-phenylpropanamido]-3-hydroxybutanamido]-3-hydroxypropanamido]-3-carboxypropanamido]-3-methylbutanamido]-3-hydroxypropanamido]-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido]-4-carboxybutanamido]acetamido}-4-carbamoylbutanamido]propanamido]propanamido]-5-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-4-carbamimidamido-1-[({[(1S)-4-carbamimidamido-1-[(carboxymethyl)carbamoyl]butyl]carbamoyl}methyl)carbamoyl]butyl]carbamoyl}-2-methylpropyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]carbamoyl}ethyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-phenylethyl]carbamoyl}-3-carboxypropyl]carbamoyl}pentyl]carbamoyl}methoxy)ethoxy]ethyl}carbamoyl)methoxy]ethoxy}ethyl)carbamoyl]-1-carboxypropyl]carbamoyl}heptadecanoic acid
DrugBank:
DB13928
Formula:
C187-H291-N45-O59
Molecular Mass:
Average: 4113.641
Monoisotopic: 4111.11537713
Synonyms:
Semaglutide / Semaglutide API
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)CC1=CNC=N1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O
InChi:
InChI=1S/C187H291N45O59/c1-18-105(10)154(180(282)208-108(13)159(261)216-133(86-114-89-200-119-50-40-39-49-117(114)119)170(272)218-129(82-102(4)5)171(273)228-152(103(6)7)178(280)215-121(53-44-72-199-186(192)193)162(264)201-91-141(242)209-120(52-43-71-198-185(190)191)161(263)204-94-151(257)258)230-172(274)131(83-111-45-33-31-34-46-111)219-167(269)126(64-69-149(253)254)214-166(268)122(51-41-42-70-195-144(245)98-290-79-78-289-76-74-197-145(246)99-291-80-77-288-75-73-196-139(240)66-61-127(183(285)286)211-140(241)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-146(247)248)212-158(260)107(12)206-157(259)106(11)207-165(267)125(60-65-138(189)239)210-142(243)92-202-163(265)123(62-67-147(249)250)213-168(270)128(81-101(2)3)217-169(271)130(85-113-56-58-116(238)59-57-113)220-175(277)135(95-233)223-177(279)137(97-235)224-179(281)153(104(8)9)229-174(276)134(88-150(255)256)221-176(278)136(96-234)225-182(284)156(110(15)237)231-173(275)132(84-112-47-35-32-36-48-112)222-181(283)155(109(14)236)227-143(244)93-203-164(266)124(63-68-148(251)252)226-184(287)187(16,17)232-160(262)118(188)87-115-90-194-100-205-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,200,233-238H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,239)(H,194,205)(H,195,245)(H,196,240)(H,197,246)(H,201,264)(H,202,265)(H,203,266)(H,204,263)(H,206,259)(H,207,267)(H,208,282)(H,209,242)(H,210,243)(H,211,241)(H,212,260)(H,213,270)(H,214,268)(H,215,280)(H,216,261)(H,217,271)(H,218,272)(H,219,269)(H,220,277)(H,221,278)(H,222,283)(H,223,279)(H,224,281)(H,225,284)(H,226,287)(H,227,244)(H,228,273)(H,229,276)(H,230,274)(H,231,275)(H,232,262)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,190,191,198)(H4,192,193,199)/t105-,106-,107-,108-,109 ,110 ,118-,120-,121-,122-,123-,124-,125-,126-,127 ,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1
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