KIMBERLY-CLARK HUGGIES® LITTLE SNUGGLERS DIAPERS
From: $62.82
An umbilical cord cut-out, perfectly shaped to gently protect your little one’s belly button as it heals. Wetness indicator helps you keep track of wet diapers by changing color when wet. Pocketed back waistband to help keep in the runny mess. Softness inside and out, with a breathable, comfy outer cover and quilted, flexible inner pad. Specially shaped to gently fit little legs.
All Variations
| SKU | Stock | Size | Packaging | Price | Quantity | Price Per | Add to Cart |
|---|---|---|---|---|---|---|---|
| SKU: KI-49695 | Stock: In Stock | Size: 1 | Packaging: 32 diapers per pack, 4 packs per case (128 diapers total) | Price: $66.58 | Price Per: case | ||
| SKU: KI-49694 | Stock: In Stock | Size: Newborn | Packaging: 31 diapers per pack, 4 packs per case (124 diapers total) | Price: $66.58 | variation_pricing_suffix: case | ||
| SKU: KI-49697 | Stock: In Stock | Size: 2 | Packaging: 29 diapers per pack, 4 packs per case (116 diapers total) | Price: $66.58 | variation_pricing_suffix: case | ||
| SKU: KI-67330 | Stock: In Stock | Size: Preemies | Packaging: 30 diapers per pack, 6 packs per case (180 diapers total) | Price: $86.94 | variation_pricing_suffix: case | ||
| SKU: KI-49699 | Stock: In Stock | Size: 4 | Packaging: 22 diapers per pack, 4 packs per case (88 diapers total) | Price: $66.58 | variation_pricing_suffix: case | ||
| SKU: KI-49706 | Stock: In Stock | Size: 5 | Packaging: 19 diapers per pack, 4 packs per case (76 diapers total) | Price: $62.82 | variation_pricing_suffix: case | ||
| SKU: KI-49698 | Stock: In Stock | Size: 3 | Packaging: 26 diapers per pack, 4 packs per case (104 diapers total) | Price: $62.82 | variation_pricing_suffix: case | ||
| SKU: KI-34717 | Stock: In Stock | Size: 1 | Packaging: 20 diapers per pack, 12 packs per case (240 diapers total) | Price: $128.55 | variation_pricing_suffix: case |
An umbilical cord cut-out, perfectly shaped to gently protect your little one’s belly button as it heals. Wetness indicator helps you keep track of wet diapers by changing color when wet. Pocketed back waistband to help keep in the runny mess. Softness inside and out, with a breathable, comfy outer cover and quilted, flexible inner pad. Specially shaped to gently fit little legs.
| Weight | 6.9500 lbs |
|---|---|
| Dimensions | 10 × 10 × 10 in |
| Size | Preemies, 1, Newborn, 2, 3, 4, 5 |
| Packaging | 30 diapers per pack, 6 packs per case (180 diapers total), 20 diapers per pack, 12 packs per case (240 diapers total), 31 diapers per pack, 4 packs per case (124 diapers total), 32 diapers per pack, 4 packs per case (128 diapers total), 29 diapers per pack, 4 packs per case (116 diapers total), 26 diapers per pack, 4 packs per case (104 diapers total), 22 diapers per pack, 4 packs per case (88 diapers total), 19 diapers per pack, 4 packs per case (76 diapers total) |
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Semaglutide API Product Description:
COA Available Product with NDC Code
Available in the US and Canada.
Semaglutide API is indicated for improving glycemic control in adults with type 2 diabetes mellitus, in conjunction with diet and exercise. The approved therapeutic doses are 0.5 mg and 1 mg. Type 2 diabetes is a chronic metabolic disorder characterized by high blood sugar, insulin resistance, and insufficient insulin production. The onset of this condition is linked to the inability of beta cells to respond to increased plasma glucose, predominantly caused by lifestyle factors such as overweight and obesity. The key feature of type 2 diabetes is insulin resistance, which reduces insulin’s effectiveness at normal concentrations. Insulin secretion is stimulated by incretins like glucagon-like peptide 1 (GLP-1), which also delays gastric emptying and induces satiety.
Mode of Action:
Semaglutide API enhances glucose control through various mechanisms, including increased insulin secretion, slower gastric emptying, and reduced postprandial glucagon and food intake. The drug mimics the activity of GLP-1, a key hormone in glucose management, thanks to structural modifications that improve its stability against degradation by enzymes like dipeptidyl peptidase-4 (DPP-4). These modifications also promote specific binding to plasma albumin and prevent incorrect binding of fatty acids, resulting in an extended half-life and improved patient compliance.
Pharmacodynamics:
Clinical trials show that semaglutide significantly reduces glycated hemoglobin (HbA1c) compared to other medications, including sitagliptin, exenatide, and insulin glargine U100. HbA1c is a standard measure of high glucose levels, reflecting long-term blood sugar control. Additionally, semaglutide has been shown to reduce body weight, lower fasting and postprandial glucose levels, and decrease fasting triglycerides and VLDL cholesterol.
Metabolism:
Semaglutide is slowly but extensively metabolized before excretion, with 83% of the administered dose found unchanged in plasma. Six different metabolites have been identified, with the major metabolite accounting for 7.7% of the dose. The drug is primarily degraded by enzymes such as DPP-4 and neural endopeptidase (NEP), which inactivate semaglutide and hydrolyze its peptide bonds.
Toxicity:
In preclinical studies, mild c-cell hyperplasia and other effects, including liver necrosis and centrilobular hypertrophy, were observed at doses significantly higher than those used clinically. High doses also resulted in ECG abnormalities and tissue vacuolation.
IUPAC:
17-{[(1R)-3-[(2-{2-[({2-[2-({[(5S)-5-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S,3R)-2-{2-[(2S)-2-{2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-2-methylpropanamido}-4-carboxybutanamido]acetamido}-3-hydroxybutanamido]-3-phenylpropanamido]-3-hydroxybutanamido]-3-hydroxypropanamido]-3-carboxypropanamido]-3-methylbutanamido]-3-hydroxypropanamido]-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido]-4-carboxybutanamido]acetamido}-4-carbamoylbutanamido]propanamido]propanamido]-5-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-4-carbamimidamido-1-[({[(1S)-4-carbamimidamido-1-[(carboxymethyl)carbamoyl]butyl]carbamoyl}methyl)carbamoyl]butyl]carbamoyl}-2-methylpropyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]carbamoyl}ethyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-phenylethyl]carbamoyl}-3-carboxypropyl]carbamoyl}pentyl]carbamoyl}methoxy)ethoxy]ethyl}carbamoyl)methoxy]ethoxy}ethyl)carbamoyl]-1-carboxypropyl]carbamoyl}heptadecanoic acid
DrugBank:
DB13928
Formula:
C187-H291-N45-O59
Molecular Mass:
Average: 4113.641
Monoisotopic: 4111.11537713
Synonyms:
Semaglutide / Semaglutide API
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)CC1=CNC=N1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O
InChi:
InChI=1S/C187H291N45O59/c1-18-105(10)154(180(282)208-108(13)159(261)216-133(86-114-89-200-119-50-40-39-49-117(114)119)170(272)218-129(82-102(4)5)171(273)228-152(103(6)7)178(280)215-121(53-44-72-199-186(192)193)162(264)201-91-141(242)209-120(52-43-71-198-185(190)191)161(263)204-94-151(257)258)230-172(274)131(83-111-45-33-31-34-46-111)219-167(269)126(64-69-149(253)254)214-166(268)122(51-41-42-70-195-144(245)98-290-79-78-289-76-74-197-145(246)99-291-80-77-288-75-73-196-139(240)66-61-127(183(285)286)211-140(241)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-146(247)248)212-158(260)107(12)206-157(259)106(11)207-165(267)125(60-65-138(189)239)210-142(243)92-202-163(265)123(62-67-147(249)250)213-168(270)128(81-101(2)3)217-169(271)130(85-113-56-58-116(238)59-57-113)220-175(277)135(95-233)223-177(279)137(97-235)224-179(281)153(104(8)9)229-174(276)134(88-150(255)256)221-176(278)136(96-234)225-182(284)156(110(15)237)231-173(275)132(84-112-47-35-32-36-48-112)222-181(283)155(109(14)236)227-143(244)93-203-164(266)124(63-68-148(251)252)226-184(287)187(16,17)232-160(262)118(188)87-115-90-194-100-205-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,200,233-238H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,239)(H,194,205)(H,195,245)(H,196,240)(H,197,246)(H,201,264)(H,202,265)(H,203,266)(H,204,263)(H,206,259)(H,207,267)(H,208,282)(H,209,242)(H,210,243)(H,211,241)(H,212,260)(H,213,270)(H,214,268)(H,215,280)(H,216,261)(H,217,271)(H,218,272)(H,219,269)(H,220,277)(H,221,278)(H,222,283)(H,223,279)(H,224,281)(H,225,284)(H,226,287)(H,227,244)(H,228,273)(H,229,276)(H,230,274)(H,231,275)(H,232,262)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,190,191,198)(H4,192,193,199)/t105-,106-,107-,108-,109 ,110 ,118-,120-,121-,122-,123-,124-,125-,126-,127 ,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1
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Lysol On-The-Go Citrus Disinfectant Wipes are your perfect companion for maintaining hygiene wherever you are. Packaged in a convenient 15-wipe count, these wipes are designed for easy transport and use on the move. With the power to kill 99.99% of viruses and bacteria, including those responsible for cold and flu, these wipes are an essential item for your hygiene kit.
Product Features:
- Powerful Disinfectant: Lysol On-The-Go Kills 99.99% of viruses and bacteria, including 8 cold and flu viruses, Salmonella, E. Coli, MRSA, Staph, and Strep viruses, along with antibiotic-resistant bacteria.
- Allergen Removal: Effectively removes more than 95% of allergens, making it ideal for users sensitive to common allergens.
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Lysol On-The-Go Citrus Disinfectant Wipes provide the trusted disinfecting power of Lysol in a compact, travel-friendly package. Whether you’re commuting, traveling, or simply out and about, these wipes offer a quick and convenient way to ensure the surfaces you come into contact with are sanitized, keeping you and your loved ones protected from germs and bacteria.
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ProActive Self Adhesive Electrode is a versatile and reusable electrode that can be used with most TENS and muscle electro stimulators. With a built-in conductive gel surface that remains effective for up to 30 uses,ProActive Self Adhesive Electrode is pre-wired and pre-gelled for easy and convenient application. The flexible cloth backing allows the electrode to conform to all body surfaces, while the rounded edges prevent electrode curl-up. The hypo-allergenic gel keeps the skin soft and the anchored pigtail prevents wire pull-out, increasing the usage life. Available in a variety of shapes and sizes, these latex-free electrodes are perfect for multiple treatment zones.
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