ASPEN SURGICAL SMOKE SHARK™ II SMOKE EVACUATOR
From: $52.21
A light-weight, ultra-quiet and compact design allowing for simplified operation and storage. The Smoke Shark II minimizing exposure to smoke plume during electrosurgical procedure increasing facility safety and reducing hazardous risk. Covered 3-port, 4-phase, filter design provides versatile accessory and procedure setup while decreasing risk of cross contamination. The Smoke Shark II Smoke Evacuator includes a standard two year manufacturer warranty.
All Variations
| SKU | Stock | Sterility | Gauge | Component | Packaging | Price | Quantity | Price Per | Add to Cart |
|---|---|---|---|---|---|---|---|---|---|
| SKU: AS-SE02 | Stock: In Stock | Sterility: | Gauge: | Component: Smoke Evacuator Unit | Packaging: | Price: $2,111.23 | Price Per: Each | ||
| SKU: AS-SELW | Stock: In Stock | Sterility: Non-Sterile | Gauge: 7/8 | Component: Wand | Packaging: 3 wand per box (3 wand total) | Price: $52.21 | variation_pricing_suffix: box | ||
| SKU: AS-SEAS | Stock: In Stock | Sterility: | Gauge: | Component: Arm Stand | Packaging: | Price: $200.27 | variation_pricing_suffix: each | ||
| SKU: AS-SERF | Stock: In Stock | Sterility: Non-Sterile | Gauge: 7/8 to 1/4 | Component: Reducer Fitting | Packaging: 10 fitting per box (10 fitting total) | Price: $82.87 | variation_pricing_suffix: box | ||
| SKU: AS-SERFS | Stock: In Stock | Sterility: Sterile | Gauge: | Component: Reducer Fitting | Packaging: 10 fitting per box (10 fitting total) | Price: $108.01 | variation_pricing_suffix: box | ||
| SKU: AS-786TS | Stock: In Stock | Sterility: Sterile | Gauge: 7/8 | Component: Tube | Packaging: 24 tube per box (24 tube total) | Price: $225.76 | variation_pricing_suffix: box | ||
| SKU: AS-SETWS | Stock: In Stock | Sterility: Sterile | Gauge: 7/8 | Component: Tube | Packaging: 24 tube per box (24 tube total) | Price: $400.65 | variation_pricing_suffix: box | ||
| SKU: AS-786T | Stock: In Stock | Sterility: Non-Sterile | Gauge: 7/8 | Component: Tube | Packaging: 24 tube per box, 18 boxes per plate (432 tube total) | Price: $187.60 | variation_pricing_suffix: box | ||
| SKU: AS-SETW | Stock: In Stock | Sterility: Non-Sterile | Gauge: 7/8 | Component: Tube | Packaging: 24 tube per box (24 tube total) | Price: $358.47 | variation_pricing_suffix: box | ||
| SKU: AS-SEVL | Stock: In Stock | Sterility: Non-Sterile | Gauge: 7/8 to 3/8 | Component: Tubing | Packaging: 5 tube per box (5 tube total) | Price: $113.15 | variation_pricing_suffix: box | ||
| SKU: AS-SF35 | Stock: In Stock | Sterility: | Gauge: | Component: Filter | Packaging: | Price: $300.64 | variation_pricing_suffix: each | ||
| SKU: AS-FSSEP | Stock: In Stock | Sterility: | Gauge: | Component: Foot Switch | Packaging: | Price: $196.83 | variation_pricing_suffix: each |
A light-weight, ultra-quiet and compact design allowing for simplified operation and storage. The Smoke Shark II minimizing exposure to smoke plume during electrosurgical procedure increasing facility safety and reducing hazardous risk. Covered 3-port, 4-phase, filter design provides versatile accessory and procedure setup while decreasing risk of cross contamination. The Smoke Shark II Smoke Evacuator includes a standard two year manufacturer warranty.
| Weight | 9.9500 lbs |
|---|---|
| Dimensions | 10 × 10 × 10 in |
| Sterility | Non-Sterile, Sterile |
| Gauge | 7/8, 7/8 to 1/4, 7/8 to 3/8 |
| Component | Tube, Wand, Arm Stand, Reducer Fitting, Tubing, Foot Switch, Smoke Evacuator Unit, Filter |
| Packaging | 24 tube per box, 18 boxes per plate (432 tube total), 3 wand per box (3 wand total), 24 tube per box (24 tube total), 10 fitting per box (10 fitting total), 5 tube per box (5 tube total) |
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Semaglutide API Product Description:
COA Available Product with NDC Code
Available in the US and Canada.
Semaglutide API is indicated for improving glycemic control in adults with type 2 diabetes mellitus, in conjunction with diet and exercise. The approved therapeutic doses are 0.5 mg and 1 mg. Type 2 diabetes is a chronic metabolic disorder characterized by high blood sugar, insulin resistance, and insufficient insulin production. The onset of this condition is linked to the inability of beta cells to respond to increased plasma glucose, predominantly caused by lifestyle factors such as overweight and obesity. The key feature of type 2 diabetes is insulin resistance, which reduces insulin’s effectiveness at normal concentrations. Insulin secretion is stimulated by incretins like glucagon-like peptide 1 (GLP-1), which also delays gastric emptying and induces satiety.
Mode of Action:
Semaglutide API enhances glucose control through various mechanisms, including increased insulin secretion, slower gastric emptying, and reduced postprandial glucagon and food intake. The drug mimics the activity of GLP-1, a key hormone in glucose management, thanks to structural modifications that improve its stability against degradation by enzymes like dipeptidyl peptidase-4 (DPP-4). These modifications also promote specific binding to plasma albumin and prevent incorrect binding of fatty acids, resulting in an extended half-life and improved patient compliance.
Pharmacodynamics:
Clinical trials show that semaglutide significantly reduces glycated hemoglobin (HbA1c) compared to other medications, including sitagliptin, exenatide, and insulin glargine U100. HbA1c is a standard measure of high glucose levels, reflecting long-term blood sugar control. Additionally, semaglutide has been shown to reduce body weight, lower fasting and postprandial glucose levels, and decrease fasting triglycerides and VLDL cholesterol.
Metabolism:
Semaglutide is slowly but extensively metabolized before excretion, with 83% of the administered dose found unchanged in plasma. Six different metabolites have been identified, with the major metabolite accounting for 7.7% of the dose. The drug is primarily degraded by enzymes such as DPP-4 and neural endopeptidase (NEP), which inactivate semaglutide and hydrolyze its peptide bonds.
Toxicity:
In preclinical studies, mild c-cell hyperplasia and other effects, including liver necrosis and centrilobular hypertrophy, were observed at doses significantly higher than those used clinically. High doses also resulted in ECG abnormalities and tissue vacuolation.
IUPAC:
17-{[(1R)-3-[(2-{2-[({2-[2-({[(5S)-5-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S,3R)-2-{2-[(2S)-2-{2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-2-methylpropanamido}-4-carboxybutanamido]acetamido}-3-hydroxybutanamido]-3-phenylpropanamido]-3-hydroxybutanamido]-3-hydroxypropanamido]-3-carboxypropanamido]-3-methylbutanamido]-3-hydroxypropanamido]-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido]-4-carboxybutanamido]acetamido}-4-carbamoylbutanamido]propanamido]propanamido]-5-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-4-carbamimidamido-1-[({[(1S)-4-carbamimidamido-1-[(carboxymethyl)carbamoyl]butyl]carbamoyl}methyl)carbamoyl]butyl]carbamoyl}-2-methylpropyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]carbamoyl}ethyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-phenylethyl]carbamoyl}-3-carboxypropyl]carbamoyl}pentyl]carbamoyl}methoxy)ethoxy]ethyl}carbamoyl)methoxy]ethoxy}ethyl)carbamoyl]-1-carboxypropyl]carbamoyl}heptadecanoic acid
DrugBank:
DB13928
Formula:
C187-H291-N45-O59
Molecular Mass:
Average: 4113.641
Monoisotopic: 4111.11537713
Synonyms:
Semaglutide / Semaglutide API
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)CC1=CNC=N1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O
InChi:
InChI=1S/C187H291N45O59/c1-18-105(10)154(180(282)208-108(13)159(261)216-133(86-114-89-200-119-50-40-39-49-117(114)119)170(272)218-129(82-102(4)5)171(273)228-152(103(6)7)178(280)215-121(53-44-72-199-186(192)193)162(264)201-91-141(242)209-120(52-43-71-198-185(190)191)161(263)204-94-151(257)258)230-172(274)131(83-111-45-33-31-34-46-111)219-167(269)126(64-69-149(253)254)214-166(268)122(51-41-42-70-195-144(245)98-290-79-78-289-76-74-197-145(246)99-291-80-77-288-75-73-196-139(240)66-61-127(183(285)286)211-140(241)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-146(247)248)212-158(260)107(12)206-157(259)106(11)207-165(267)125(60-65-138(189)239)210-142(243)92-202-163(265)123(62-67-147(249)250)213-168(270)128(81-101(2)3)217-169(271)130(85-113-56-58-116(238)59-57-113)220-175(277)135(95-233)223-177(279)137(97-235)224-179(281)153(104(8)9)229-174(276)134(88-150(255)256)221-176(278)136(96-234)225-182(284)156(110(15)237)231-173(275)132(84-112-47-35-32-36-48-112)222-181(283)155(109(14)236)227-143(244)93-203-164(266)124(63-68-148(251)252)226-184(287)187(16,17)232-160(262)118(188)87-115-90-194-100-205-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,200,233-238H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,239)(H,194,205)(H,195,245)(H,196,240)(H,197,246)(H,201,264)(H,202,265)(H,203,266)(H,204,263)(H,206,259)(H,207,267)(H,208,282)(H,209,242)(H,210,243)(H,211,241)(H,212,260)(H,213,270)(H,214,268)(H,215,280)(H,216,261)(H,217,271)(H,218,272)(H,219,269)(H,220,277)(H,221,278)(H,222,283)(H,223,279)(H,224,281)(H,225,284)(H,226,287)(H,227,244)(H,228,273)(H,229,276)(H,230,274)(H,231,275)(H,232,262)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,190,191,198)(H4,192,193,199)/t105-,106-,107-,108-,109 ,110 ,118-,120-,121-,122-,123-,124-,125-,126-,127 ,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1
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